Prof. Dr. Sabine Gaisser

Lebenslauf

Sabine Gaisser ist Biologin und arbeitete nach ihrer Promotion am Lehrstuhl Mikrobiologie/Membranphysiologie der Universität Tübingen als Postdoktorandin im Department of Pathology und im Department of Biochemistry der University of Cambridge, UK. Im Jahr 2001 wechselte sie zur Firma Biotica Technology Limited, Cambridge, UK. Im September 2007 wurde sie als Professorin für die Lehrgebiete Mikrobiologie und Technische Mikrobiologie an die Hochschule Biberach berufen.

Publikationen

(33) Kendrew SG, Petkovic H, Gaisser S, Ready SJ et al. (2013) Recombinant strains for the enhanced production of bioengineered rapalogs. Metab Eng. 15:167-73

(32) Gaisser S, Carletti I, Schell U, Graupner PR, Sparks TC, Martin CJ and B Wilkinson. (2009) Glycosylation engineering of spinosyn analogues containing an L-olivose moiety. Org Biomol Chem. 7:1705-8

(31) Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B and S Gaisser (2008). Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. Org Biomol Chem. 6:3315-27

(30) Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B and CJ Martin (2008). Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem. 51:5494-7

(29) Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM and MQ Zhang (2008). Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 51:2853-7

(28) Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B and RM Sheridan (2006). Rapamycin biosynthesis: Elucidation of gene product function. Org Biomol Chem. 4:3565-8

(27) Novel Compounds, UK Patent Application: GB 0606542.9, filed on 31.03.2006

(26) Novel Compounds, UK Patent Application: GB 0606548.6, filed on 31.03.2006

(25) Novel Compounds, UK Patent Application: GB 0606554.4, filed on 31.03.2006

(24) Novel Compounds, UK Patent Application: GB 0526473.4, filed on 24.12.2005

(23) WO 2005/054265 Gaisser S, Leadlay PF, Haydock SF, HA McArthur (2005). Polyketides and their synthesis. PCT International Application, WO 2005/054265, filed 28.03.2004, published 16.06.2005

(22) Gregory MA, Petkovic H, Lill RE, Moss SJ, Wilkinson B, Gaisser S, Leadlay PF and RM Sheridan (2005). Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angew. Chem. Int. Ed. 44:4757-4760

(21) Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J and PF Leadlay (2004). Isolation and characterisation of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by Streptomyces hygroscopicus. Angew. Chem. Int. Ed. Engl. 43:2551-2553

(20) WO04/007709 Gregory MA, Gaisser S, Petkovic H, Moss S (2004). Production of polyketides and other natural products. PCT International Application, filed 16.07.2003, published 22.01.2004

(19) Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall, McArthur HA, Staunton J and PF Leadlay (2003). Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Org. Biomol. Chem. 1:2840-2847

(18) Gaisser S, Lill R, Staunton J, Mendez C, Salas J, and PF Leadlay (2002). Parallel pathways for oxidation of 14-membered macrolactones in Saccharopolyspora erythraea. Mol. Microbiol. 44:771-781

(17) Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, and J Staunton (2002). Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chem. Commun. 21:618-619

(16) Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, and A Bechthold (2002). Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tu57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1. Microbiology 148:373-379

(15) Gaisser S, Lill R, Wirtz G, Grolle F, Staunton J, and PF Leadlay (2001). New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. Mol. Microbiol. 41:1223-1231

(14) WO01/79520 Leadlay PF, Staunton J, and S Gaisser (2000). Hybrid glycosylated products and their production and use. PCT International Application, filed 17.04.2001, published 25.10.2001

(13) Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton J, and PF Leadlay (2000). A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Mol. Microbiol. 36:391-401

(12) Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, and J Staunton (2000). Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chem. Biol. 7:111-117

(11) WO99/05283 Fromentin C, Michel JM, Raynal MC, Salah-Bey K, Cortés J, Gaisser S, Leadlay PF, Mendez C, and J Salas (1999). Biosynthesis genes and transfer of 6-desoxyhexoses in Saccharopolyspora erythraea and in Streptomyces antibioticus and their use

(10) Gaisser S, Böhm GA, Cortés J, Doumith M, Raynal MC, Dhillon N, and PF Leadlay (1998). Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Mol. Gen. Genet. 258:78-88

(9) Gaisser S and PF Leadlay (1998). Sugaring the pill by design. Nature Biotechnol. 16:19-20

(8) Rowe CJ, Cortés J, Gaisser S, Staunton J, and PF Leadlay (1998). Construction of new vectors for high-level expression in actinomycetes. Gene 216: 215-223

(7) Gaisser S, Böhm GA, Cortés J, and PF Leadlay (1997). Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Mol. Gen. Genet. 256:239-251

(6) Gaisser S and C Hughes (1997). A locus coding for putative non-ribosomal peptide/polyketide synthase functions is mutated in a swarming-defective Proteus mirabilis strain. Mol. Gen. Genet. 253:415-427

(5) Braun V, Gaisser S, Herrmann C, Kampfenkel K, Killmann H, and I Traub (1996). Energy-coupled transport across the outer membrane of Escherichia coli: ExbB binds ExbD and TonB in vitro, and leucine 132 in the periplasmic region and aspartate 25 in the transmembrane region are important for ExbD activity. J. Bacteriol. 178:2836-2845

(4) Traub I, Gaisser S, and V Braun (1993). Activity domains of the TonB protein. Mol. Microbiol. 8:409-423

(3) Braun V, Gaisser S, Glaser C, Harkness R, Ölschläger T, and J Mende (1992). Import and Export of Colicin M. In: Bacteriocins, Microcins and Lantibiotics (eds.). NATO ASI Series, Vol. H 65. Springer-Verlag, Heidelberg

(2) Gaisser S and V Braun (1991). The tonB gene of Serratia marcescens: sequence, activity and partial complementation of Escherichia coli tonB mutants. Mol. Microbiol. 5:2777-2787

(1) Angerer A, Gaisser S, and V Braun (1990) Nucleotide sequences of the sfuA, sfuB and sfuC genes of Serratia marcescens suggest a periplasmic-binding-protein-dependent iron transport mechanism. J. Bacteriol. 172:572-578