


The focus of our research group is the investigation and development of innovative concepts for molecular cell line engineering. A range of projects are currently under way to optimize various production cell lines for the manufacturing of biological drugs. These include biopharmaceuticals like antibodies for tumor therapy, but also viral vectors for gene therapy and novel entities as exosomes for drug delivery. We are particularly interested in applying aspects of synthetic biology, non-coding RNAs and OMICs technologies to generate designer cell lines for future applications.
The Otte Lab hosts master and PhD students as well as postdoctoral students since 2011. We cooperate with numerous national and international academic laboratories and industrial partners. Our funding is provided by national research funding agencies as well as industrial cooperation partners. We are open for new projects in the area of applied and innovative cell development research.
Unraveling what makes a monoclonal antibody difficult-to-express: From intracellular accumulation to incomplete folding and degradation via ERAD. Mathias S, Wippermann A, Raab N, Zeh N, Handrick R, Gorr I, Schulz P, Fischer S, Gamer M, Otte K.Biotechnol Bioeng. 2020 Jan;117(1):5-16. doi: 10.1002/bit.27196. Epub 2019 Nov 15. PMID: 31631329