The focus of our research group is the investigation and development of innovative concepts for molecular cell line engineering. A range of projects are currently under way to optimize various production cell lines for the manufacturing of biopharmaceuticals like antibodies for tumor therapy. We are particularly interested in applying aspects of synthetic biology, protein glycosylation, non-coding RNA and OMICs technologies to generate designer cell lines for future applications.

The Otte Lab hosts master and PhD students as well as postdoctoral students since 2011. We cooperate with numerous national and international academic laboratories and industrial partners. Our funding is provided by national research funding agencies as well as industrial cooperation partners. We are open for new projects in the area of applied and innovative cell development research.

Projects in overview:


2021

Scientific publications

2020

Scientific publications

2019

Scientific publications

Invited conference presentations

  • Kerstin Otte, Difficult to express proteins:
    Identification of intracellular production bottlenecks in CHO cells
    Bioprocess Summit Europe, Lisbon (Portugal), 19.-21.3.2019
     
  • Kerstin Otte, Forschung gemeinsam mit Unternehmen
    Forschung an HAW, Bernhäuser Forst, 28.-29.3.2019
     
  • Kerstin Otte, Engineering of mammalian cell lines to remove production bottlenecks
    RPP10 A comparative view on host physiology, Kreta (Griechenland), 24.-27.4.2019
     
  • Kerstin Otte, Molecular Modulation of Cellular Signaling to Enhance protein production
    Gordon Research Conference Biotherapeutics and Vaccines Development, Houston (USA), 6.-11.1.2019

2018

Scientific publications

Invited conference presentations

  • Kerstin Otte, CRISPR/CAS9 mediated knockout of microRNAs for precise cell engineering
    Cell Culture Engineering (CCE) XVI, Tampa (USA), 6-11.5.2018
     
  • Kerstin Otte, CRISPR/CAS9 MEDIATED KNOCKOUT OF MICRORNAS FOR PECISE CELL ENGINEERING
    Cell Culture Engineering (CCE) XVI, Tampa (USA), 6-11.5.2018
     
  • Kerstin Otte, Identification of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy PEGS Boston 2018, Boston (USA), 30.4.-4.5.2018
     
  • Kerstin Otte, Latest developments on MicroRNAs for Next-Generation Cell Engineering 11th Annual Proteins & Antibodies Congress, London (UK), 16-18.4.2018
    Kerstin Otte, ENGINEERING OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC MICRORNAS
    BPI WEST, San Francisco (USA), 19-22.3.2018

2017

Scientific publications

Invited conference presentations

  • Kerstin Otte, Effective MicroRNAs for Next-Generation CHO Cell Engineering The 2nd International Advanced Biomanufacturing Conference, Sheffield (UK), 22-23.5.2017
     
  • Kerstin Otte, The latest research findings on engineering cell lines by using
    MicroRNAs Bioprocess International European Summit, Cell Line Development & Engineering, Amsterdam (Netherlands), 24.-27.4.2017
     
  • Kerstin Otte, MicroRNAs for optimized production: towards a deeper understanding
    of underlying mechanisms Cell Culture and Downstream World Congress 2017, Munich (Germany), 16.1.2017

2016

Scientific publications

Invited conference presentations

  • Kerstin Otte, Effective microRNAs for cell line engineering to enhance productivity
    ACTIP meeting, Frankfurt (Germany), 1-2.12.2016
     
  • Kerstin Otte, Carriers in Academia
    1st ESACT Frontiers Retreat 2016, Lyon (France), 20-22.10.2016
     
  • Kerstin Otte, Effective miRNAs for cell line engineering and underlying cellular mechanisms of action.

2015

Scientific publications

Invited conference presentations

  • Kerstin Otte, Scale-Down Models Enable Identication of microRNAs to Enhance
    Cellular Performance of Mammalian Cell Factories
    PEGS Europe, Lissabon (Spain), 6.11.2015
     
  • Kerstin Otte, Tiny but Mighty - Harnessing microRNAs for Next-generation Cell
    Engineering of Biopharmaceutical Production Cells
    3rd Protein Expression, Purification and Characterization Conference, Boston (USA), 23.10.2015
     
  • Kerstin Otte, Cell line Engineering to Boost Biopharmaceutical Production.
    8th Student Symposium on Molecular Medicine, Ulm University, 18.4.2015
     
  • Kerstin Otte, Werdegang Professorin
    Jubiläumsveranstaltung der LaKof BW, Hochschule Esslingen (Germany), 10.3.2015

2014

Scientific publications

Invited conference presentations

  • Kerstin Otte, Cell Line Engineering Using the Potential of microRNAs
    PEGS Europe, Lisbon (Portugal), 6.11.2014
     
  • Kerstin Otte, The potential of miRNAs in genetic engineering of CHO cells
    MipTec, Basel (Swizerland), 25.10.2014

2013

Scientific publications

2004 and older

Scientific publications

  • Identification and characterization of production bottlenecks in CHO cells
  • Increased bioassay productivity and quality by standardization and automation (Automation
  • Crossing Barriers with bio-based therapeutics
  • CAP-Exsosomes
  • Entwicklung von Hochproduktionszelllinien für ressourcenschonende Herstellung von Biopharmazeutika
  • KPK-PBT: Kooperatives Promotionskolleg Pharmazeutische Biotechnologie